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Table 1 The Guideline for the Treatment Resistant Schizophrenia

From: Incorporating clinical guidelines through clinician decision-making

Step

Treatment

Common Examples

1

FGA #1: 1st trial of a first-generation (conventional) antipsychotic medication

haloperidol (Haldol), perphenazine (Trilafan), fluphenazine (Prolixin), loxapine (Loxitane), molindone (Moban), thiothixene (Navane) trifluoperazine (Stelazine)

2

FGA #2: 2nd trial of a first-generation antipsychotic medication

as above

3

SGA #1: 1st trial of a second-generation (atypical) antipsychotic medication

risperidone (Risperdal), aripiprazole (Abilify), quetiapine (Seroquel), olanzapine (Zyprexa), serlect (Sertindole)

4

SGA #2: 2nd trial of a second-generation antipsychotic medication

as above

5

Clozapine

clozapine (Clozaril) only